Lotus Notes Client Crashes With NSD After Updating To 6.5.1

Today I had a problem updating a Lotus Notes 5 Client to 6.5.1
After the update the client started, showed a nice redbox and ‘NSD is running’.
I did a backup of the local databases, uninstalled Lotus Notes removed the directory, cleared the registry and tried a new installation.
Again the client chrashed. I disabled the virusscanner and all unnecessary background programms. The client crashed again.
I did a closer look to that system. This w2k machine had a least 1500 Truetype fonts installed. After the fonts were moved to a backupfolder the client started properly.